Quercetin inhibits inducible ICAM-1 expression in human endothelial cells through the JNK pathway.
نویسندگان
چکیده
The cell adhesion molecule intercellular adhesion molecule-1 (ICAM-1) plays a pivotal role in inflammatory responses. Quercetin (3,3',4',5,7-pentahydroxyflavone), a naturally occurring dietary flavonol, has potent anti-inflammatory properties. The effect of quercetin on ICAM-1 expression induced by agonists phorbol 12-myristate 13-acetate (PMA) and tumor necrosis factor-α (TNF-α) in human endothelial cell line ECV304 (ECV) was investigated. Quercetin treatment downregulated both PMA- and TNF-α-induced surface expression, as well as the ICAM-1 mRNA levels, in ECV cells in a dose-dependent (10-50 μM) manner. Quercetin had no effect on PMA- or TNF-α-induced nuclear factor-κB (NF-κB) activation. However, under similar conditions a remarkable dose-dependent downregulation of activator protein-1 (AP-1) activation was observed. This decrease in AP-1 activation was observed to be associated with the inhibitory effects of quercetin on the c-Jun NH2-terminal kinase (JNK) pathway. These results suggest that quercetin downregulates both PMA- and TNF-α-induced ICAM-1 expression via inhibiting both AP-1 activation and the JNK pathway.
منابع مشابه
ACELL September 46/3
Kobuchi, Hirotsugu, Sashwati Roy, Chandan K. Sen, Hao G. Nguyen, and Lester Packer. Quercetin inhibits inducible ICAM-1 expression in human endothelial cells through the JNK pathway. Am. J. Physiol. 277 (Cell Physiol. 46): C403–C411, 1999.—The cell adhesion molecule intercellular adhesion molecule-1 (ICAM-1) plays a pivotal role in inflammatory responses. Quercetin (3,38,48,5,7-pentahydroxyflav...
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ورودعنوان ژورنال:
- The American journal of physiology
دوره 277 3 Pt 1 شماره
صفحات -
تاریخ انتشار 1999